0477 Positive Airway Pressure Therapy and Antidepressant Medication Adherence in Patients with Obstructive Sleep Apnea and Depression

Abstract Introduction Previous studies have shown that treatment of obstructive sleep apnea (OSA) with positive airway pressure (PAP) therapy in patients OSA and comorbid depression may improve response to antidepressant medication therapy. At the same time, scant evidence has examined impact PAP adherence depression. Patients adhere one be more likely other therapies or healthy behaviors a so-called “healthy user effect.” This retrospective study investigated association between newly diagnosed Methods Our data source was national sample administrative claims linked objective usage. Included either had two healthcare encounters hospitalization ICD-10 diagnosis code year prior being initiated on Adherence defined as ≥80% proportion days covered (PDC), non-adherence < 80% PDC within 180-day exposure window during starting categorized consistently adherent, intermediately not adherent based usage over 2 years. Results 36,668 were included. 27% classified 45% 28% non-adherent 68.6% used initiation. 67.7% selective serotonin reuptake inhibitor, 43.8% atypical antidepressants, 32.1% norepinephrine 10.7% tricyclic antidepressant, 0.1% monoamine oxidase inhibitor. Relative (22.2% 33.9% adherent), those also years (29.2% 45.2% 25.6% adherent). Conclusion slightly better In real-world studies, an important confounder adjust for when comparing patient outcomes. Support (if any)